555 research outputs found

    Collective Identity and Voice at the Australian Citizens' Parliament

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    This paper examines the role of collective identity and collective voice in political life. We argue that persons have an underlying predisposition to use collective dimensions, such as common identities and a public voice, in thinking and expressing themselves politically. This collective orientation, however, can be either fostered or weakened by citizens’ political experiences. Although the collective level is an important dimension in contemporary politics, conventional democratic practices do not foster it. Deliberative democracy is suggested as an environment that might allow more ground for citizens to express themselves not only in individual but also in collective terms. We examine this theoretical perspective through a case study of the Australian Citizens’ Parliament, in which transcripts are analyzed to determine the extent to which collective identities and common voice surfaced in actual discourse. We analyze the dynamics involved in the advent of collective dimensions in the deliberative process and highlight the factors—deliberation, nature of the discussion, and exceptional opportunity—that potentially facilitated the rise of group identities and common voice. In spite of the strong individualistic character of the Australian cultural identity, we nonetheless found evidence of collective identity and voice at the Citizens’ Parliament, expressed in terms of national, state, and community levels. In the conclusion, we discuss the implications of those findings for future research and practice of public deliberation

    Critical Quantum Metrology with a Finite-Component Quantum Phase Transition

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    Physical systems close to a quantum phase transition exhibit a divergent susceptibility, suggesting that an arbitrarily high precision may be achieved by exploiting quantum critical systems as probes to estimate a physical parameter. However, such an improvement in sensitivity is counterbalanced by the closing of the energy gap, which implies a critical slowing down and an inevitable growth of the protocol duration. Here, we design different metrological protocols that exploit the superradiant phase transition of the quantum Rabi model, a finite-component system composed of a single two-level atom interacting with a single bosonic mode. We show that, in spite of the critical slowing down, critical quantum optical probes can achieve a quantum-enhanced time scaling of the sensitivity in frequency-estimation protocols

    Decision analysis for the determination of biomass in the territory Tuscia Romana by geographic information system and forest management plans

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    The growing interest in the development of chains for the use of agroforestry biomass for energy demand, is due to the awareness they are a crucial element to mitigate the global climatic change effects. The true effort is to have a reliable estimation of biomass availability by some instruments like forest management plans, which allow to locate the forest supply and to know the forest biomass availability in a medium period. In this paper we carried out a decision analysis by geographic information system, in Tuscia Romana area comprising 11 municipalities for a total amount of 813 km2. An estimation was carried out taking into account the bibliographic data on the analyzed species, reporting the biomass in weight taken out by the forest cut utilization. A comparison was also performed in field on chestnut trees cut in a sampling area near Bracciano and in a close sawmill. The results show long, medium and short-term dynamics, but some critical points were found related to the process of estimation and to the real procurement of biomass in some years. The results suggest to be care in a possible project of a biomass plant

    Angiopoietin decoy secreted at tumor site impairs tumor growth and metastases by inducing local inflammation and altering neoangiogenesis

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    The extracellular domain of the receptor tyrosine kinase Tie2/TEK (exTEK) has been used as an angiopoietin decoy to study the role of angiopoietins in the tumor-host interactions, using a syngeneic model of experimental metastases and subcutaneous tumor. Soluble exTEK secreted by transfected tumor cells inhibited HUVECs from forming tubes in Matrigel. ExTEK-transfected C26 colon carcinoma and TS/A mammary tumor cells displayed reduced growth rate when injected subcutaneously, and reduced ability to form experimental metastases when injected intravenously. Immunohistochemical analysis of tumors and metastases showed increased leukocytes infiltration and signs of inflammation in exTEK-secreting compared to parental tumor, as well as impairment in neo-vessel growth and organization. However, while neoangiogenesis eventually rescued in the subcutis, it failed to organize in the experimental metastases of exTEK-secreting tumor, contributing to the hampering of metastatic growth and to increased mice survival. The reactive infiltrate of C26TEK contained a different percentage of leukocytes and was responsible for the tumor inhibition. In fact, leukopenia induced by gamma-irradiation of recipient mice or injection into interferon gamma (IFN-gamma) gene knockout (GKO) mice resulted in reduced mouse survival and an increased number of lung metastases. On the other hand, interleukin (IL)-12 treatment prolonged the survival of mice bearing subcutaneous C26TEK but not of those bearing lung metastases, suggesting that IL-12 could exert further antiangiogenic effects at the site where the tumor can restore neoangiogenesis. These results show in vivo that reduced angiopoietin availability at the tumor site induces a local inflammatory response and impairment of neoangiogenesis which act synergistically to limit tumor growth and metastasis

    DEEP CONVOLUTIONAL NEURAL NETWORKS FOR SENTIMENT ANALYSIS OF CULTURAL HERITAGE

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    Abstract. The promotion of Cultural Heritage (CH) goods has become a major challenges over the last years. CH goods promote economic development, notably through cultural and creative industries and tourism. Thus, an effective planning of archaeological, cultural, artistic and architectural sites within the territory make CH goods easily accessible. A way of adding value to these services is making them capable of providing, using new technologies, a more immersive and stimulating fruition of information. In this light, an effective contribution can be provided by sentiment analysis. The sentiment related to a monument can be used for its evaluation considering that if it is positive, it influences its public image by increasing its value. This work introduces an approach to estimate the sentiment of Social Media pictures CH related. The sentiment of a picture is identified by an especially trained Deep Convolutional Neural Network (DCNN); aftewards, we compared the performance of three DCNNs: VGG16, ResNet and InceptionResNet. It is interesting to observe how these three different architectures are able to correctly evaluate the sentiment of an image referred to a ancient monument, historical buildings, archaeological sites, museum objects, and more. Our approach has been applied to a newly collected dataset of pictures from Instagram, which shows CH goods included in the UNESCO list of World Heritage properties.</p

    HOXB7: a key factor for tumo-associated angiogenic switch.

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    We had demonstrated previously a functional bridge between altered homebox (HOX) gene expression and tumor progression through HOXB7 transactivation of basic fibroblast growth factor. Here, we have studied whether HOXB7, in addition to basic fibroblast growth factor, may induce other genes directly or indirectly related to neoangiogenesis and tumor invasion. Parental, beta-galactosidase-transduced, and HOXB7-transduced SkBr3 cell lines were examined for the expression of several growth factors and growth factor receptors involved in the proliferative and angiogenic processes. Vascular endothelial growth factor, melanoma growth-stimulatory activity/growth-related oncogenene alpha, interleukin-8, and angiopoietin-2 were up-regulated by HOXB7 transduction. The exception was angiopoietin-1 expression that was abrogated. Additional analyses included the expression levels of enzymes such as matrix metalloprotease (MMP)-2 and MMP-9 and heparanase, capable of proteolytic degradation of extracellular matrix and basement membranes. Results showed an induction of only MMP-9. The functional implication of such a finding was tested using an in vitro coculture assay in a three-dimensional matrix. A delay of differentiation with persistent nests of proliferating cells was found in endothelial cells cocultured with HOXB7-transduced SkBr3 cells. Tumorigenicity of these cells has been evaluated in vivo. Xenograft into athymic nude mice showed that SkBr3/HOXB7 cells developed tumors in mice, either irradiated or not, whereas parental SkBr3 cells did not show any tumor take unless mice were sublethally irradiated. Comparison of tumor nodules for vascularization by CD-31 and CD-34 immunostaining revealed an increased number of blood vessels in tumors expressing HOXB7. Together, the results indicate HOXB7 as a key factor up-regulating a variety of proangiogenic stimuli. Thus, HOXB7 gene or protein is a target to aim at to inhibit tumor-associated neoangiogenesis, considering the number and the redundancy of proangiogenic molecules that should be targeted one by one to theoretically achieve the same effect
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